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Article

Physical interaction between neurofibromin and serotonin 5-HT6 receptor promotes receptor constitutive activity.

Proceedings of the National Academy of Sciences of the United States of America - 25 Oct 2016

Deraredj Nadim Wissem, Chaumont-Dubel Séverine, Madouri Fahima, Cobret Laetitia, De Tauzia Marie-Ludivine, Zajdel Pawel, Bénédetti Hélène, Marin Philippe, Morisset-Lopez Séverine

Abstract excerpt

Active G protein-coupled receptor (GPCR) conformations not only are promoted by agonists but also occur in their absence, leading to constitutive activity. Association of GPCRs with intracellular protein partners might be one of the mechanisms underlying GPCR constitutive activity. Here, we show that serotonin 5 hydroxytryptamine 6 (5-HT6) receptor constitutively activates the Gs/adenylyl cyclase pathway in...

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Identifiers

PMID: 27791021
DOI: 10.1073/pnas.1600914113
PMCID: PMC5087017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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