Article
Parathyroid tumor suppressor on 1p: analysis of the p18 cyclin-dependent kinase inhibitor gene as a candidate.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Sept 1997
Tahara H, Smith A P, Gaz R D, Zariwala M, Xiong Y, Arnold A
Abstract excerpt
Loss of chromosome arm 1p DNA is the most common molecular defect thus far observed in human parathyroid adenomas, suggesting that 1p is the location of a putative tumor suppressor gene (or genes) whose inactivation contributes frequently to parathyroid tumorigenesis. To narrow the genomic location of this tumor suppressor gene, we analyzed 25 sporadic parathyroid adenomas for allelic loss of polymorphic DNA loci...
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