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Article

Frequent loss of chromosome arm 1p DNA in parathyroid adenomas.

Genes, chromosomes & cancer - 1 May 1995

Cryns V L, Yi S M, Tahara H, Gaz R D, Arnold A

Abstract excerpt

Two molecular defects have been described in parathyroid adenomas: rearrangement and overexpression of the PRAD1/cyclin D1 oncogene and allelic loss of chromosome 11 DNA, often including the multiple endocrine neoplasia type 1 (MEN1) putative tumor suppressor gene region. In an effort to identify additional parathyroid tumor suppressor genes, we examined 25 parathyroid adenomas for tumor-specific allelic loss of...

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Identifiers

PMID: 7541648
DOI: 10.1002/gcc.2870130103

Genes

MEN1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Frequent loss of chromosome arm 1p DNA in parathyroid adenomas.PMID 7541648Read ↗

Putative parathyroid tumor suppressor on 1p: independent molecular mechanisms of tumorigenesis from 11q allelic loss.Semantic proximity Read ↗

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Genomic localization of novel candidate tumor suppressor gene loci in human parathyroid adenomas.Semantic proximity Read ↗

Deletion mapping on the distal third region of chromosome 1p in multiple endocrine neoplasia type IIA.Semantic proximity Read ↗

Parathyroid tumor suppressor on 1p: analysis of the p18 cyclin-dependent kinase inhibitor gene as a candidate.Semantic proximity Read ↗

Allelic loss on chromosome 1p is Associated with progression and lymph node metastasis of primary breast carcinomaSemantic proximity Read ↗

Loss of chromosome arm 9p DNA and analysis of the p16 and p15 cyclin-dependent kinase inhibitor genes in human parathyroid adenomas.Semantic proximity Read ↗

Allelic deletions on chromosome 11q13 in multiple tumors from individual MEN1 patients.Semantic proximity Read ↗

Loss of heterozygosity in sporadic parathyroid tumours: involvement of chromosome 1 and the MEN1 gene locus in 11q13.Semantic proximity Read ↗

Chromosome 1 alterations in breast cancer: allelic loss on 1p and 1q is related to lymphogenic metastases and poor prognosis.Semantic proximity Read ↗

Allelic loss from chromosome 11 in parathyroid tumors.Semantic proximity Read ↗

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