Frequent loss of chromosome arm 1p DNA in parathyroid adenomas.

doi:10.1002/gcc.2870130103

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Article

Frequent loss of chromosome arm 1p DNA in parathyroid adenomas.

Genes, chromosomes & cancer - 1 May 1995

Cryns V L, Yi S M, Tahara H, Gaz R D, Arnold A

Abstract excerpt

Two molecular defects have been described in parathyroid adenomas: rearrangement and overexpression of the PRAD1/cyclin D1 oncogene and allelic loss of chromosome 11 DNA, often including the multiple endocrine neoplasia type 1 (MEN1) putative tumor suppressor gene region. In an effort to identify...

Topics

Adenoma
Adolescent
Adult
Aged
Alleles
Chromosomes, Human, Pair 1
Cyclin D1
Cyclins
DNA
DNA, Neoplasm
Female
Follow-Up Studies
Gene Deletion
Gene Expression Regulation, Neoplastic
Gene Rearrangement
Genetic Markers
Heterozygote
Humans

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