Article
Rod plateaux during dark adaptation in Sorsby's fundus dystrophy and vitamin A deficiency.
Investigative ophthalmology & visual science - 1 Aug 1997
Cideciyan A V, Pugh E N, Lamb T D, Huang Y, Jacobson S G
Abstract excerpt
PURPOSE: To investigate the transitory plateaux observed during dark adaptation after partial bleaches in Sorsby's fundus dystrophy (SFD) and in systemic vitamin A deficiency (VAD). METHODS: Psychophysical dark adaptation functions were measured after bleaching exposures isomerizing from 2% to 99% of the rhodopsin. Narrow-band stimuli of 1.7 degrees diameter and 200 msec duration were presented at an eccentricity...
Topics
- Adult
- Dark Adaptation
- Fundus Oculi
- Humans
- Male
- Middle Aged
- Mutation
- Photic Stimulation
- Protease Inhibitors
- Proteins
- Retinal Degeneration
- Retinal Rod Photoreceptor Cells
- Tissue Inhibitor of Metalloproteinase-3
- Vitamin A Deficiency
