Article
Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man.
Proceedings of the National Academy of Sciences of the United States of America - 6 Jan 1998
Cideciyan A V, Zhao X, Nielsen L, Khani S C, Jacobson S G, Palczewski K
Abstract excerpt
Rhodopsin kinase (RK), a specialized G-protein-coupled receptor kinase expressed in retina, is involved in quenching of light-induced signal transduction in photoreceptors. The role of RK in recovery after photoactivation has been explored in vitro and in vivo experimentally but has not been spec...
Topics
- Animals
- COS Cells
- Child
- Electroretinography
- Exons
- Eye Proteins
- G-Protein-Coupled Receptor Kinase 1
- Gene Deletion
- Genotype
- Humans
- Kinetics
- Male
- Night Blindness
- Polymerase Chain Reaction
- Protein Kinases
- Vision, Ocular