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Article

Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man.

Proceedings of the National Academy of Sciences of the United States of America - 6 Jan 1998

Cideciyan A V, Zhao X, Nielsen L, Khani S C, Jacobson S G, Palczewski K

Abstract excerpt

Rhodopsin kinase (RK), a specialized G-protein-coupled receptor kinase expressed in retina, is involved in quenching of light-induced signal transduction in photoreceptors. The role of RK in recovery after photoactivation has been explored in vitro and in vivo experimentally but has not been specifically defined in humans. We investigated the effects on human vision of a mutation in the RK gene causing Oguchi...

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Identifiers

PMID: 9419375
DOI: 10.1073/pnas.95.1.328
PMCID: PMC18214

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ERG

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Null mutation in the rhodopsin kinase gene slows recovery kinetics of rod and cone phototransduction in man.PMID 9419375Read ↗

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Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness.Semantic proximity Read ↗

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Structure and mechanisms of function of visual system proteins.Semantic proximity Read ↗

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Opsins with mutations at the site of chromophore attachment constitutively activate transducin but are not phosphorylated by rhodopsin kinase.Semantic proximity Read ↗

[Physiological roles of rhodopsin phosphorylation and dephosphorylation and its relationship with retinitis pigmentosa].Semantic proximity Read ↗

Biochemical evidence for pathogenicity of rhodopsin kinase mutations correlated with the oguchi form of congenital stationary night blindness.Semantic proximity Read ↗

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Enhanced arrestin facilitates recovery and protects rods lacking rhodopsin phosphorylation.Semantic proximity Read ↗

Alterations in the photoactivation pathway of rhodopsin mutants associated with retinitis pigmentosa.Semantic proximity Read ↗

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