Article
Spontaneous mutation at the hypervariable mouse minisatellite locus Ms6-hm: flanking DNA sequence and analysis of germline and early somatic mutation events.
Proceedings. Biological sciences - 23 Sept 1991
Kelly R, Gibbs M, Collick A, Jeffreys A J
Abstract excerpt
Hypervariability at minisatellite loci is maintained by spontaneous mutation to new-length alleles. At the most variable loci, mutation rate is directly measurable by pedigree analysis. The mouse minisatellite locus Ms6-hm has a germline mutation rate of 2.5% per gamete and is therefore one of th...
Topics
- Alleles
- Animals
- Base Sequence
- Chromosome Mapping
- DNA, Satellite
- Female
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Molecular Sequence Data
- Mosaicism
- Mutation
- Repetitive Sequences, Nucleic Acid