Complex gene conversion events in germline mutation at human minisatellites.

doi:10.1038/ng0294-136

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Article

Complex gene conversion events in germline mutation at human minisatellites.

Nature genetics - 1 Feb 1994

Jeffreys A J, Tamaki K, MacLeod A, Monckton D G, Neil D L, Armour J A

Abstract excerpt

Mutation at the human minisatellites MS32, MS205 and MS31A has been investigated by characterizing mutant alleles in pedigrees and in the case of MS32 by direct analysis of mutant molecules in single sperm. Most mutations at all three loci are polar, involving the preferential gain of a few repea...

Topics

Alleles
DNA, Satellite
Gene Amplification
Gene Conversion
Germ-Line Mutation
Humans
Male
Models, Genetic
Pedigree
Polymerase Chain Reaction
Polymorphism, Genetic
Repetitive Sequences, Nucleic Acid
Spermatozoa

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