Article
Mutation rate heterogeneity and the generation of allele diversity at the human minisatellite MS205 (D16S309).
Human molecular genetics - 1 Nov 1996
May C A, Jeffreys A J, Armour J A
Abstract excerpt
Many tandemly repeated minisatellite loci display extreme levels of length variation as a consequence of high rates of spontaneous germline mutation altering repeat copy number. Direct screening for new allele lengths by small-pool PCR has shown that instability at the human minisatellite locus MS205 (D16S309) is largely germline specific and usually results in the gain or loss of just a few repeat units....
Topics
- Alleles
- Genetic Variation
- Germ-Line Mutation
- Humans
- Male
- Minisatellite Repeats
- Mutagenesis
- Polymerase Chain Reaction
- Spermatozoa