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Article

A novel single molecule analysis of spontaneous and radiation-induced mutation at a mouse tandem repeat locus.

Mutation research - 20 Mar 2002

Yauk Carole L, Dubrova Yuri E, Grant Gemma R, Jeffreys Alec J

Abstract excerpt

Expanded simple tandem repeat (ESTR) loci include some of the most unstable DNA in the mouse genome and have been extensively used in pedigree studies of germline mutation. We now show that repeat DNA instability at the mouse ESTR locus Ms6-hm can also be monitored by single molecule PCR analysis of genomic DNA. Unlike unstable human minisatellites which mutate almost exclusively in the germline by a meiotic...

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Source

Identifiers

PMID: 11890944
DOI: 10.1016/s0027-5107(02)00005-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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