Article
Activation of the ALT pathway for telomere maintenance can affect other sequences in the human genome.
Human molecular genetics - 1 Jul 2005
Jeyapalan Jennie N, Varley Helen, Foxon Jenny L, Pollock Raphael E, Jeffreys Alec J, Henson Jeremy D, Reddel Roger R, Royle Nicola J
Abstract excerpt
Immortal human cells maintain telomere length by the expression of telomerase or through the alternative lengthening of telomeres (ALT). The ALT mechanism involves a recombination-like process that allows the rapid elongation of shortened telomeres. However, it is not known whether activation of the ALT pathway affects other sequences in the genome. To address this we have investigated, in ALT-expressing cell...
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