Article
Hypermutable minisatellites, a human affair?
Genomics - 1 Apr 2003
Bois Philippe R J
Abstract excerpt
Minisatellites are a class of highly polymorphic GC-rich tandem repeats. They include some of the most variable loci in the human genome, with mutation rates ranging from 0.5% to >20% per generation. Structurally, they consist of 10- to 100-bp intermingled variant repeats, making them ideal tools for dissecting mechanisms of instability at tandem repeats. Distinct mutation processes generate rare intra-allelic...
Topics
- Humans
- Minisatellite Repeats
- Mutation
- Radiation, Ionizing
- Recombination, Genetic