Article
DNA renaturation activity of the SMC complex implicated in chromosome condensation.
Nature - 21 Aug 1997
Sutani T, Yanagida M
Abstract excerpt
Chromosome condensation occurs in mitosis before the separation of sister chromatids, and requires DNA topoisomerase II and a group of proteins called SMCs. The resulting condensed chromosomes in metaphase have a complex hierarchical structure. SMCs, the components of condensed chromosomes, are also required for the separation of sister chromatids and gene dosage compensation, and are found in a range of...
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