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Article

Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint.

Cell cycle (Georgetown, Tex.) - 1 Jan 2000

Goloudina Anastasia, Yamaguchi Hiroshi, Chervyakova Daria B, Appella Ettore, Fornace Albert J, Bulavin Dmitry V

Abstract excerpt

Degradation of Cdc25A phosphatase is an ubiquitous feature of stress. There are some discrepancies in the reported roles for different phosphorylation sites in the regulation of Cdc25A stability. Using a panel of doxycycline-inducible phosphorylation mutants we show that the stability of human Cdc25A protein is dependent upon phosphorylation at S75. In non-stressed conditions and in non-mitotic cells, Cdc25A is...

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PMID: 12963847

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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