Article
Restricted structural gene polymorphism in the Mycobacterium tuberculosis complex indicates evolutionarily recent global dissemination.
Proceedings of the National Academy of Sciences of the United States of America - 2 Sept 1997
Sreevatsan S, Pan X, Stockbauer K E, Connell N D, Kreiswirth B N, Whittam T S, Musser J M
Abstract excerpt
One-third of humans are infected with Mycobacterium tuberculosis, the causative agent of tuberculosis. Sequence analysis of two megabases in 26 structural genes or loci in strains recovered globally discovered a striking reduction of silent nucleotide substitutions compared with other human bacterial pathogens. The lack of neutral mutations in structural genes indicates that M. tuberculosis is evolutionarily...
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