Article
Evolutionary history and global spread of the Mycobacterium tuberculosis Beijing lineage.
Nature genetics - 1 Mar 2015
Merker Matthias, Blin Camille, Mona Stefano, Duforet-Frebourg Nicolas, Lecher Sophie, Willery Eve, Blum Michael G B, Rüsch-Gerdes Sabine, Mokrousov Igor, Aleksic Eman, Allix-Béguec Caroline, Antierens Annick, Augustynowicz-Kopeć Ewa, Ballif Marie, Barletta Francesca, Beck Hans Peter, Barry Clifton E, Bonnet Maryline, Borroni Emanuele, Campos-Herrero Isolina, Cirillo Daniela, Cox Helen, Crowe Suzanne, Crudu Valeriu, Diel Roland, Drobniewski Francis, Fauville-Dufaux Maryse, Gagneux Sébastien, Ghebremichael Solomon, Hanekom Madeleine, Hoffner Sven, Jiao Wei-wei, Kalon Stobdan, Kohl Thomas A, Kontsevaya Irina, Lillebæk Troels, Maeda Shinji, Nikolayevskyy Vladyslav, Rasmussen Michael, Rastogi Nalin, Samper Sofia, Sanchez-Padilla Elisabeth, Savic Branislava, Shamputa Isdore Chola, Shen Adong, Sng Li-Hwei, Stakenas Petras, Toit Kadri, Varaine Francis, Vukovic Dragana, Wahl Céline, Warren Robin, Supply Philip, Niemann Stefan, Wirth Thierry
Abstract excerpt
Mycobacterium tuberculosis strains of the Beijing lineage are globally distributed and are associated with the massive spread of multidrug-resistant (MDR) tuberculosis in Eurasia. Here we reconstructed the biogeographical structure and evolutionary history of this lineage by genetic analysis of 4,987 isolates from 99 countries and whole-genome sequencing of 110 representative isolates. We show that this lineage...
Topics
- Biological Evolution
- Evolution, Molecular
- Genome, Bacterial
- Genotype