Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Antagonism between EGFR and Wingless signalling in the larval cuticle of Drosophila.

Development (Cambridge, England) - 1 Aug 1997

Szüts D, Freeman M, Bienz M

Abstract excerpt

Signalling by the epidermal growth factor receptor (EGFR) plays a critical role in the segmental patterning of the ventral larval cuticle in Drosophila: by expressing a dominant-negative EGFR molecule or Spitz, an activating ligand of EGFR, we show that EGFR signalling specifies the anterior dent...

Topics

Abdomen
Animals
Body Patterning
DNA-Binding Proteins
Drosophila
Drosophila Proteins
Epidermal Growth Factor
ErbB Receptors
Eye Proteins
Homeodomain Proteins
Insect Proteins
Larva
Ligands

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Proteins

Mutation

Nerve Tissue Proteins

Nuclear Proteins

Phenotype

Source

Identifiers

PMID: 9272961
DOI: 10.1242/dev.124.16.3209

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9272961-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Antagonism between EGFR and Wingless signalling in the larval cuticle of Drosophila.PMID 9272961Read ↗

EGF receptor signalling protects smooth-cuticle cells from apoptosis during Drosophila ventral epidermis development.Semantic proximity Read ↗

Spitz and Wingless, emanating from distinct borders, cooperate to establish cell fate across the Engrailed domain in the Drosophila epidermis.Semantic proximity Read ↗

Segment polarity gene interactions modulate epidermal patterning in Drosophila embryos.Semantic proximity Read ↗

Planar polarity and actin dynamics in the epidermis of Drosophila.Semantic proximity Read ↗

Interactions between the EGF receptor and DPP pathways establish distinct cell fates in the tracheal placodes.Semantic proximity Read ↗

Mutual antagonism between signals secreted by adjacent wingless and engrailed cells leads to specification of complementary regions of the Drosophila parasegment.Semantic proximity Read ↗

Signalling crosstalk at the leading edge controls tissue closure dynamics in the Drosophila embryo.Semantic proximity Read ↗

Bristles induce bracts via the EGFR pathway on Drosophila legs.Semantic proximity Read ↗

EGFR-dependent network interactions that pattern Drosophila eggshell appendages.Semantic proximity Read ↗

Functional analysis of Wingless reveals a link between intercellular ligand transport and dorsal-cell-specific signaling.Semantic proximity Read ↗

Cell shape and epithelial patterning in the Drosophila embryonic epidermis.Semantic proximity Read ↗

A role for wingless in the segmental gradient of Drosophila?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.