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Article

Bristles induce bracts via the EGFR pathway on Drosophila legs.

Mechanisms of development - 1 Sept 2002

Held Lewis I

Abstract excerpt

A long-standing mystery in Drosophila has been: how do certain bristles induce adjacent cells to make bracts (a type of thick hair) on their proximal side? The apparent answer, based on loss- and gain-of-function studies, is that they emit a signal that neighbors then transduce via the epidermal growth factor receptor pathway. Suppressing this pathway removes bracts, while hyperactivating it evokes bracts...

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Identifiers

PMID: 12204262
DOI: 10.1016/s0925-4773(02)00212-5

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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