Article
HLA class II haplotype and sequence analysis support a role for DQ in narcolepsy.
Immunogenetics - 1 Jan 1997
Ellis M C, Hetisimer A H, Ruddy D A, Hansen S L, Kronmal G S, McClelland E, Quintana L, Drayna D T, Aldrich M S, Mignot E
Abstract excerpt
A systematic haplotype and sequencing analysis of the HLA-DR and -DQ region in patients with narcolepsy was performed. Five new (CA)n microsatellite markers were generated and positioned on the physical map across the HLA-DQB1-DQA1-DRB1 interval. Haplotypes for these new markers and the three HLA loci were established using somatic cell hybrids generated from patients. A four-marker haplotype surrounding the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.
