Narcolepsy-Associated HLA Class I Alleles Implicate Cell-Mediated Cytotoxicity.

doi:10.5665/sleep.5532

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Article

Narcolepsy-Associated HLA Class I Alleles Implicate Cell-Mediated Cytotoxicity.

Sleep - 1 Mar 2016

Tafti Mehdi, Lammers Gert J, Dauvilliers Yves, Overeem Sebastiaan, Mayer Geert, Nowak Jacek, Pfister Corinne, Dubois Valérie, Eliaou Jean-François, Eberhard Hans-Peter, Liblau Roland, Wierzbicka Aleksandra, Geisler Peter, Bassetti Claudio L, Mathis Johannes, Lecendreux Michel, Khatami Ramin, Heinzer Raphaël, Haba-Rubio José, Feketeova Eva, Baumann Christian R, Kutalik Zoltán, Tiercy Jean-Marie

Abstract excerpt

STUDY OBJECTIVES: Narcolepsy with cataplexy is tightly associated with the HLA class II allele DQB1*06:02. Evidence indicates a complex contribution of HLA class II genes to narcolepsy susceptibility with a recent independent association with HLA-DPB1. The cause of narcolepsy is supposed be an autoimmune attack against hypocretin-producing neurons. Despite the strong association with HLA class II, there is no...

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PMID: 26518595
DOI: 10.5665/sleep.5532
PMCID: PMC4763366

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