Article
Narcolepsy-Associated HLA Class I Alleles Implicate Cell-Mediated Cytotoxicity.
Sleep - 1 Mar 2016
Tafti Mehdi, Lammers Gert J, Dauvilliers Yves, Overeem Sebastiaan, Mayer Geert, Nowak Jacek, Pfister Corinne, Dubois Valérie, Eliaou Jean-François, Eberhard Hans-Peter, Liblau Roland, Wierzbicka Aleksandra, Geisler Peter, Bassetti Claudio L, Mathis Johannes, Lecendreux Michel, Khatami Ramin, Heinzer Raphaël, Haba-Rubio José, Feketeova Eva, Baumann Christian R, Kutalik Zoltán, Tiercy Jean-Marie
Abstract excerpt
STUDY OBJECTIVES: Narcolepsy with cataplexy is tightly associated with the HLA class II allele DQB1*06:02. Evidence indicates a complex contribution of HLA class II genes to narcolepsy susceptibility with a recent independent association with HLA-DPB1. The cause of narcolepsy is supposed be an autoimmune attack against hypocretin-producing neurons. Despite the strong association with HLA class II, there is no...
Topics
- Alleles
- CD8-Positive T-Lymphocytes
- Case-Control Studies
- Cataplexy
- Epitopes
- Europe
- Genetic Predisposition to Disease
- HLA-DQ beta-Chains
- Haplotypes