Article
Association between human leukocyte antigen class II-DR-DQ and narcolepsy: a case control study.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine - 1 Dec 2024
Bacelar Andrea, Fernandez Oscar, Paradella Eduardo, Rodrigues Raimundo Nonato, de Castro Moreno Claudia Roberta, Alvarenga Regina
Abstract excerpt
STUDY OBJECTIVES: Narcolepsy is a neurologic disorder characterized by irresistible sleep attacks. Although its etiology is unknown, it is strongly associated with genetic variances in the human leukocyte antigen (HLA) complex. We investigated the association of HLA class II-DR-DQ alleles in a sample of patients with narcolepsy-cataplexy (narcolepsy type 1 [NT1]) and patients with narcolepsy without cataplexy...
Topics
- Humans
- Narcolepsy
- Male
- Female
- Case-Control Studies
- Adult
- HLA-DQ beta-Chains
- Polysomnography
- Alleles
- HLA-DRB1 Chains
- Haplotypes
- HLA-DQ Antigens
- Middle Aged
- Genetic Predisposition to Disease