Article
Control of microtubule dynamics by oncoprotein 18: dissection of the regulatory role of multisite phosphorylation during mitosis.
Molecular and cellular biology - 1 Sept 1997
Larsson N, Marklund U, Gradin H M, Brattsand G, Gullberg M
Abstract excerpt
Oncoprotein 18 (Op18; also termed p19, 19K, metablastin, stathmin, and prosolin) is a conserved protein that regulates microtubule (MT) dynamics. Op18 is multisite phosphorylated on four Ser residues during mitosis; two of these Ser residues, Ser-25 and Ser-38, are targets for cyclin-dependent pr...
Topics
- Binding Sites
- Cyclin-Dependent Kinases
- Dimerization
- Down-Regulation
- HeLa Cells
- Humans
- Interphase
- Microtubule Proteins
- Microtubules
- Mitosis
- Phenotype
- Phosphoproteins