Article
Global regulation of the interphase microtubule system by abundantly expressed Op18/stathmin.
Molecular biology of the cell - 1 Jul 2008
Sellin Mikael E, Holmfeldt Per, Stenmark Sonja, Gullberg Martin
Abstract excerpt
Op18/stathmin (Op18), a conserved microtubule-depolymerizing and tubulin heterodimer-binding protein, is a major interphase regulator of tubulin monomer-polymer partitioning in diverse cell types in which Op18 is abundant. Here, we addressed the question of whether the microtubule regulatory function of Op18 includes regulation of tubulin heterodimer synthesis. We used two human cell model systems, K562 and...
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