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Article

Op18/stathmin mediates multiple region-specific tubulin and microtubule-regulating activities.

The Journal of cell biology - 20 Sept 1999

Larsson N, Segerman B, Howell B, Fridell K, Cassimeris L, Gullberg M

Abstract excerpt

Oncoprotein18/stathmin (Op18) is a regulator of microtubule (MT) dynamics that binds tubulin heterodimers and destabilizes MTs by promoting catastrophes (i.e., transitions from growing to shrinking MTs). Here, we have performed a deletion analysis to mechanistically dissect Op18 with respect to (a) modulation of tubulin GTP hydrolysis and exchange, (b) tubulin binding in vitro, and (c) tubulin association and...

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Identifiers

PMID: 10491392
DOI: 10.1083/jcb.146.6.1289
PMCID: PMC2156119

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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