Article
Molecular characterization of a mutation affecting the amount of Streptococcus pneumoniae penicillin-binding protein 3.
Microbial drug resistance (Larchmont, N.Y.) - 1 Jan 1997
Selakovitch-Chenu L, Giammarinaro P, Sicard M
Abstract excerpt
We have studied the molecular structure of the gene for the penicillin binding protein (PBP 3) of the Streptococcus pneumoniae wild-type strain and a laboratory mutant strain that exhibits a reduced amount of this protein on PBP gels. This mutation affects cefotaxime resistance when transferred into resistant strains. We have sequenced the PBP3 gene, dacA, and upstream regions from the wild-type isogenic strain...
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