Article
Capsule biosynthesis and basic metabolism in Streptococcus pneumoniae are linked through the cellular phosphoglucomutase.
Journal of bacteriology - 1 Apr 2000
Hardy G G, Caimano M J, Yother J
Abstract excerpt
Synthesis of the type 3 capsular polysaccharide of Streptococcus pneumoniae requires UDP-glucose (UDP-Glc) and UDP-glucuronic acid (UDP-GlcUA) for production of the [3)-beta-D-GlcUA-(1-->4)-beta-D-Glc-(1-->](n) polymer. The generation of UDP-Glc proceeds by conversion of Glc-6-P to Glc-1-P to UDP-Glc and is mediated by a phosphoglucomutase (PGM) and a Glc-1-P uridylyltransferase, respectively. Genes encoding both...
Topics
- Amino Acid Sequence
- Bacterial Capsules
- Base Sequence
- Cell Division
- Chromosome Mapping
- Cloning, Molecular
- Cytoplasm
- Genes, Bacterial
- Genetic Complementation Test
- Molecular Sequence Data
- Mutagenesis, Insertional
- Mutation
- Phenotype
- Phosphoglucomutase