Article
Mosaic pbpX genes of major clones of penicillin-resistant Streptococcus pneumoniae have evolved from pbpX genes of a penicillin-sensitive Streptococcus oralis.
Molecular microbiology - 1 Jun 1994
Sibold C, Henrichsen J, König A, Martin C, Chalkley L, Hakenbeck R
Abstract excerpt
Penicillin-resistant clinical isolates of Streptococcus pneumoniae contain mosaic penicillin-binding protein (PBP) genes that encode PBPs with decreased affinity for beta-lactam antibiotics. The mosaic blocks are believed to be the result of gene transfer of homologous PBP genes from related peni...
Topics
- Amino Acid Sequence
- Base Sequence
- Biological Evolution
- Carrier Proteins
- Cefotaxime
- Cloning, Molecular
- DNA, Bacterial
- Genes, Bacterial
- Genetic Variation
- Microbial Sensitivity Tests
- Molecular Sequence Data
- Penicillin Resistance
- Penicillin-Binding Proteins
- Penicillins
- Recombination, Genetic
- Sequence Analysis, DNA
- Streptococcus
- Streptococcus pneumoniae