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Mosaic pbpX genes of major clones of penicillin-resistant Streptococcus pneumoniae have evolved from pbpX genes of a penicillin-sensitive Streptococcus oralis.

Molecular microbiology - 1 Jun 1994

Sibold C, Henrichsen J, König A, Martin C, Chalkley L, Hakenbeck R

Abstract excerpt

Penicillin-resistant clinical isolates of Streptococcus pneumoniae contain mosaic penicillin-binding protein (PBP) genes that encode PBPs with decreased affinity for beta-lactam antibiotics. The mosaic blocks are believed to be the result of gene transfer of homologous PBP genes from related penicillin-resistant species. We have now identified a gene homologous to the pneumococcal PBP2x gene (pbpX) in a...

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PMID: 7934893
DOI: 10.1111/j.1365-2958.1994.tb01089.x

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