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Article

Biochemical characterization of Streptococcus pneumoniae penicillin-binding protein 2b and its implication in beta-lactam resistance.

Antimicrobial agents and chemotherapy - 1 May 2004

Pagliero Estelle, Chesnel Laurent, Hopkins Julie, Croizé Jacques, Dideberg Otto, Vernet Thierry, Di Guilmi Anne Marie

Abstract excerpt

Extensive use of beta-lactam antibiotics has led to the selection of pathogenic streptococci resistant to beta-lactams due to modifications of the penicillin-binding proteins (PBPs). PBP2b from Streptococcus pneumoniae is a monofunctional (class B) high-molecular-weight PBP catalyzing the transpeptidation between adjacent stem peptides of peptidoglycan. The transpeptidase domain of PBP2b isolated from seven...

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Identifiers

PMID: 15105143
DOI: 10.1128/AAC.48.5.1848-1855.2004
PMCID: PMC400559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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