Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evolution of penicillin resistance in Streptococcus pneumoniae; the role of Streptococcus mitis in the formation of a low affinity PBP2B in S. pneumoniae.

Molecular microbiology - 1 Aug 1993

Dowson C G, Coffey T J, Kell C, Whiley R A

Abstract excerpt

Penicillin-resistant strains of Streptococcus pneumoniae possess forms of penicillin-binding proteins (PBPs) that have a low affinity for penicillin compared to those from penicillin-sensitive strains. PBP genes from penicillin-resistant isolates are very variable and have a mosaic structure composed of blocks of nucleotides that are similar to those found in PBP genes from penicillin-sensitive isolates and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Bacterial Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Base Sequence

Share to Carrier Proteins

Share to Genes, Bacterial

Share to Genetic Variation

Share to Molecular Sequence Data

Share to Recombination, Genetic

Source

Identifiers

PMID: 8412708
DOI: 10.1111/j.1365-2958.1993.tb01723.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evolution of penicillin resistance in Streptococcus pneumoniae; the role of Streptococcus mitis in the formation of a low affinity PBP2B in S. pneumoniae.PMID 8412708Read ↗

S treptococcus pneumoniae R 6 interspecies transformation: genetic analysis of penicillin resistance determinants and genome‐wide recombination eventsSemantic proximity Read ↗

Mosaic genes and their role in penicillin‐resistant <i>Streptococcus pneumoniae</i> (minireview)Semantic proximity Read ↗

Mosaic pbpX genes of major clones of penicillin-resistant Streptococcus pneumoniae have evolved from pbpX genes of a penicillin-sensitive Streptococcus oralis.Semantic proximity Read ↗

Penicillin-resistant viridans streptococci have obtained altered penicillin-binding protein genes from penicillin-resistant strains of Streptococcus pneumoniae.Semantic proximity Read ↗

Molecular Mechanisms of β-Lactam Resistance in Streptococcus PneumoniaeSemantic proximity Read ↗

Diversity among clinical isolates of penicillin-resistant Streptococcus mitis: indication for a PBP1-dependent way to reach high levels of penicillin resistance.Semantic proximity Read ↗

The multidrug-resistant PMEN1 pneumococcus is a paradigm for genetic successSemantic proximity Read ↗

Restricted Sequence Variation in Streptococcus pyogenes Penicillin Binding Proteins.Semantic proximity Read ↗

Penicillin-Binding Proteins as Resistance Determinants in Clinical Isolates of Streptococcus pneumoniaeSemantic proximity Read ↗

Identical Penicillin-Binding Domains in Penicillin-Binding Proteins of <i>Streptococcus pneumoniae</i> Clinical Isolates with Different Levels of β-Lactam ResistanceSemantic proximity Read ↗

Molecular analysis of pbp2b in Streptococcus pneumonia isolated from clinical and normal flora samples.Semantic proximity Read ↗

Extensive variation in the ddl gene of penicillin-resistant Streptococcus pneumoniae results from a hitchhiking effect driven by the penicillin-binding protein 2b gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.