Article
Penicillin-binding proteins in Streptococcus pneumoniae: alterations during development of intrinsic penicillin resistance.
Journal of chemotherapy (Florence, Italy) - 1 Apr 1991
Hakenbeck R, Briese T, Laible G, Martin C, Schuster C
Abstract excerpt
Four out of the five high molecular weight penicillin-binding proteins (PBPs) of Streptococcus pneumoniae are involved in the development of intrinsic penicillin resistance. In beta-lactam resistant laboratory mutants, point mutations in the PBP 2x-genes were identified that result in low penicil...
Topics
- Anti-Bacterial Agents
- Bacterial Proteins
- Carrier Proteins
- Cefotaxime
- Escherichia coli
- Hexosyltransferases
- Muramoylpentapeptide Carboxypeptidase
- Mutation
- Penicillin Resistance
- Penicillin-Binding Proteins
- Peptidyl Transferases
- Streptococcus pneumoniae