Molecular characterization of cap3A, a gene from the operon required for the synthesis of the capsule of Streptococcus pneumoniae type 3: sequencing of mutations responsible for the unencapsulated phenotype and localization of the capsular cluster on the pneumococcal chromosome.

Abstract excerpt

The complete nucleotide sequence of the cap3A gene of Streptococcus pneumoniae, which is directly responsible for the transformation of some unencapsulated, serotype 3 mutants to the encapsulated phenotype, has been determined. This gene encodes a protein of 394 amino acids with a predicted M(r)...

Topics

• Amino Acid Sequence
• Bacterial Capsules
• Bacterial Proteins
• Base Sequence
• Chromosomes, Bacterial
• Cloning, Molecular
• Genes, Bacterial
• Molecular Sequence Data
• Multigene Family
• Mutation
• Operon
• Phenotype
• Restriction Mapping