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Article

An evaluation of tumor necrosis factor microsatellite alleles in genetic susceptibility to multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Nov 1995

Sandberg-Wollheim M, Ciusani E, Salmaggi A, Pociot F

Abstract excerpt

We have analyzed the distribution of tumor necrosis factor (TNF) a and -b microsatellite alleles in HLA-DQ and -DR typed Swedish patients with multiple sclerosis (MS) (n = 122) and ethnically matched control subjects (n = 178). We found significant differences in the frequencies of TNFa and TNFb alleles between patients and controls. TNFaII was significantly associated with MS. This was also the case for the...

Topics

Alleles
Evaluation Studies as Topic
Gene Frequency
Genetic Predisposition to Disease
HLA-DQ Antigens
HLA-DQ alpha-Chains
HLA-DQ beta-Chains
HLA-DR2 Antigen
Humans
Lymphotoxin-alpha
Microsatellite Repeats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multiple Sclerosis

Sweden

Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 9345451
DOI: 10.1177/135245859500100309

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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