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Article

RAS residues that are distant from the GDP binding site play a critical role in dissociation factor-stimulated release of GDP.

The EMBO journal - 1 Aug 1992

Verrotti A C, Créchet J B, Di Blasi F, Seidita G, Mirisola M G, Kavounis C, Nastopoulos V, Burderi E, De Vendittis E, Parmeggiani A

Abstract excerpt

We have previously shown that a conserved glycine at position 82 of the yeast RAS2 protein is involved in the conversion of RAS proteins from the GDP- to the GTP-bound form. We have now investigated the role of glycine 82 and neighbouring amino acids of the distal switch II region in the physiological mechanism of activation of RAS. We have introduced single and double amino acid substitutions at positions 80-83...

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Identifiers

PMID: 1639059
DOI: 10.1002/j.1460-2075.1992.tb05353.x
PMCID: PMC556765

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Source receipt: pubmed, retrieved 7 Sept 2026.

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