Article
RAS residues that are distant from the GDP binding site play a critical role in dissociation factor-stimulated release of GDP.
The EMBO journal - 1 Aug 1992
Verrotti A C, Créchet J B, Di Blasi F, Seidita G, Mirisola M G, Kavounis C, Nastopoulos V, Burderi E, De Vendittis E, Parmeggiani A
Abstract excerpt
We have previously shown that a conserved glycine at position 82 of the yeast RAS2 protein is involved in the conversion of RAS proteins from the GDP- to the GTP-bound form. We have now investigated the role of glycine 82 and neighbouring amino acids of the distal switch II region in the physiolo...
Topics
- Adenylyl Cyclases
- Amino Acid Sequence
- Base Sequence
- Binding Sites
- Cell Membrane
- Fungal Proteins
- GTP-Binding Proteins
- Genes, Fungal
- Genotype
- Glycine
- Guanosine Diphosphate
- Guanylyl Imidodiphosphate
- Kinetics
- Magnesium