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Article

The nucleotide exchange factor Cdc24p may be regulated by auto-inhibition.

The EMBO journal - 10 Mar 2004

Shimada Yukiko, Wiget Philippe, Gulli Marie-Pierre, Bi Efrei, Peter Matthias

Abstract excerpt

Site-specific activation of the Rho-type GTPase Cdc42p by its guanine-nucleotide exchange factor (GEF) Cdc24p is critical for the establishment of cell polarity. Here we show that binding of Cdc24p to the small GTPase Rsr1p/Bud1p is required for its recruitment to the incipient bud site. Rsr1p/Bud1p binds to the CH-domain of Cdc24p, which is essential for its function in vivo. We have identified a cdc24-mutant...

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Identifiers

PMID: 14988726
DOI: 10.1038/sj.emboj.7600124
PMCID: PMC380979

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The nucleotide exchange factor Cdc24p may be regulated by auto-inhibition.PMID 14988726Read ↗

The Rsr1/Bud1 GTPase interacts with itself and the Cdc42 GTPase during bud-site selection and polarity establishment in budding yeast.Semantic proximity Read ↗

Two active states of the Ras-related Bud1/Rsr1 protein bind to different effectors to determine yeast cell polarity.Semantic proximity Read ↗

A mechanism of Bud1p GTPase action suggested by mutational analysis and immunolocalization.Semantic proximity Read ↗

Localization of the Rsr1/Bud1 GTPase involved in selection of a proper growth site in yeast.Semantic proximity Read ↗

The upstream regulator, Rsr1p, and downstream effectors, Gic1p and Gic2p, of the Cdc42p small GTPase coordinately regulate initiation of budding in Saccharomyces cerevisiae.Semantic proximity Read ↗

BUD2 encodes a GTPase-activating protein for Bud1/Rsr1 necessary for proper bud-site selection in yeast.Semantic proximity Read ↗

The shared role of the Rsr1 GTPase and Gic1/Gic2 in Cdc42 polarization.Semantic proximity Read ↗

Yeast BUD5, encoding a putative GDP-GTP exchange factor, is necessary for bud site selection and interacts with bud formation gene BEM1.Semantic proximity Read ↗

Localization of Bud2p, a GTPase-activating protein necessary for programming cell polarity in yeast to the presumptive bud site.Semantic proximity Read ↗

Interactions between the bud emergence proteins Bem1p and Bem2p and Rho-type GTPases in yeast.Semantic proximity Read ↗

Msb1 interacts with Cdc42, Boi1, and Boi2 and may coordinate Cdc42 and Rho1 functions during early stage of bud development in budding yeast.Semantic proximity Read ↗

Overexpression of Bud5p can suppress mutations in the Gsp1p guanine nucleotide exchange factor Prp20p in Saccharomyces cerevisiae.Semantic proximity Read ↗

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