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Article

Mutations of Ha-ras p21 that define important regions for the molecular mechanism of the SDC25 C-domain, a guanine nucleotide dissociation stimulator.

The EMBO journal - 1 Jul 1992

Mistou M Y, Jacquet E, Poullet P, Rensland H, Gideon P, Schlichting I, Wittinghofer A, Parmeggiani A

Abstract excerpt

The SDC25 C-domain is a very active guanine nucleotide dissociation stimulator (GDS) isolated from Saccharomyces cerevisiae which acts equally well on Ha-ras p21 and yeast RAS2. These properties make the SDC25 C-domain a suitable tool to study the basic mechanism of a GDS. The action of the SDC25 C-domain was analysed by mutation of structurally important regions of p21. Substitutions that influence the...

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Identifiers

PMID: 1628612
DOI: 10.1002/j.1460-2075.1992.tb05303.x
PMCID: PMC556713

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Mutations of Ha-ras p21 that define important regions for the molecular mechanism of the SDC25 C-domain, a guanine nucleotide dissociation stimulator.PMID 1628612Read ↗

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