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Article

Crk family adaptor proteins trans-activate c-Abl kinase.

Genes to cells : devoted to molecular & cellular mechanisms - 1 May 2001

Shishido T, Akagi T, Chalmers A, Maeda M, Terada T, Georgescu M M, Hanafusa H

Abstract excerpt

BACKGROUND: c-Abl kinase is activated in response to a variety of biological stimuli. Crk family adaptor proteins can interact physically with c-Abl and be involved in the activation of c-Abl kinase. RESULTS: We report that the Crk family of adaptor proteins act as trans-acting activators of c-Abl kinase. The interaction of the amino-terminal Src-homology (SH) 3 domain of c-Crk and the proline-rich motifs of...

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Identifiers

PMID: 11380621
DOI: 10.1046/j.1365-2443.2001.00431.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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