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Article

Involvement of the adapter protein CRKL in integrin-mediated adhesion.

Oncogene - 3 Jun 1999

Uemura N, Salgia R, Ewaniuk D S, Little M T, Griffin J D

Abstract excerpt

CRKL, an SH2-SH3-SH3 adapter protein, is one of the major tyrosine phosphoproteins detected in primary leukemic neutrophils from patients with CML. CRKL binds directly to BCR/ABL through its N-terminal SH3 domain, suggesting it may be involved in BCR/ABL signal transduction. However, the biological function of CRKL in either normal or leukemic cells is still largely unknown. In this study, we have examined the...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10362355
DOI: 10.1038/sj.onc.1202689

Genes

CRKL
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Involvement of the adapter protein CRKL in integrin-mediated adhesion.PMID 10362355Read ↗

p130CAS Forms a Signaling Complex with the Adapter Protein CRKL in Hematopoietic Cells Transformed by the BCR/ABL OncogeneSemantic proximity Read ↗

The CRKL Adaptor Protein Transforms Fibroblasts and Functions in Transformation by the BCR-ABL OncogeneSemantic proximity Read ↗

CRKL Links p210BCR/ABL with Paxillin in Chronic Myelogenous Leukemia CellsSemantic proximity Read ↗

Crkl enhances leukemogenesis in BCR/ABL P190 transgenic mice.Semantic proximity Read ↗

Essential roles of Crk and CrkL in fibroblast structure and motility.Semantic proximity Read ↗

Deletion of the Src Homology 3 Domain and C-terminal Proline-rich Sequences in Bcr-Abl Prevents Abl Interactor 2 Degradation and Spontaneous Cell Migration and Impairs LeukemogenesisSemantic proximity Read ↗

BCR/ABL P190 transgenic mice develop leukemia in the absence of Crkl.Semantic proximity Read ↗

Rap1 is activated by erythropoietin or interleukin-3 and is involved in regulation of beta1 integrin-mediated hematopoietic cell adhesion.Semantic proximity Read ↗

Crk family adaptor proteins trans-activate c-Abl kinase.Semantic proximity Read ↗

Breast cancer anti-estrogen resistance 3 (BCAR3) protein augments binding of the c-Src SH3 domain to Crk-associated substrate (p130cas).Semantic proximity Read ↗

Activation of the focal adhesion kinase signaling pathway by structural alterations in the carboxyl-terminal region of c-Crk II.Semantic proximity Read ↗

Crk adapter proteins promote an epithelial-mesenchymal-like transition and are required for HGF-mediated cell spreading and breakdown of epithelial adherens junctions.Semantic proximity Read ↗

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