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Article

Apoptotic regulation by the Crk adapter protein mediated by interactions with Wee1 and Crm1/exportin.

Molecular and cellular biology - 1 Mar 2002

Smith Jesse J, Richardson D Ashley, Kopf Jan, Yoshida Minoru, Hollingsworth Robert E, Kornbluth Sally

Abstract excerpt

The adapter protein Crk contains an SH2 domain and two SH3 domains. Through binding of particular ligands to the SH2 domain and the N-terminal SH3 domain, Crk has been implicated in a number of signaling processes, including regulation of cell growth, cell motility, and apoptosis. We report here that the C-terminal SH3 domain, never shown to bind any specific signaling molecules, contains a binding site for the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11839808
DOI: 10.1128/MCB.22.5.1412-1423.2002
PMCID: PMC134685

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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