Article

MDM2 and Prognosis

2004-01-01

Abstract excerpt

Abstract The cellular stress response pathway regulated by the p53 tumor suppressor is critical to the maintenance of genomic integrity and to the prevention of oncogenic transformation. Intracellular levels of p53 are tightly regulated by an autoregulatory feedback loop comprised of p53 and MDM2. It might be predicted that disruption of this loop, either through p53 mutation or overexpression of MDM2, would be a...

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Identifiers and source

Literature Corpus work: a83bb38f-4230-5049-9441-ee6bb04239d2
DOI: 10.1158/1541-7786.1.2.1

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