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Article

Mutational analysis of the Drosophila sister-chromatid cohesion protein ORD and its role in the maintenance of centromeric cohesion.

Genetics - 1 Aug 1997

Bickel S E, Wyman D W, Orr-Weaver T L

Abstract excerpt

The ord gene is required for proper segregation of all chromosomes in both male and female Drosophila meiosis. Here we describe the isolation of a null ord allele and examine the consequences of ablating ord function. Cytologically, meiotic sister-chromatid cohesion is severely disrupted in flies lacking ORD protein. Moreover, the frequency of missegregation in genetic tests is consistent with random segregation...

Topics

Alleles
Animals
Carrier Proteins
Cell Cycle Proteins
Centromere
Drosophila
Drosophila Proteins
Female
Gene Deletion
Genetic Complementation Test
Male
Meiosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Sister Chromatid Exchange

Spermatocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 9258677
DOI: 10.1093/genetics/146.4.1319
PMCID: PMC1208078

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