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Article

Mutational analysis of the Drosophila sister-chromatid cohesion protein ORD and its role in the maintenance of centromeric cohesion.

Genetics - 1 Aug 1997

Bickel S E, Wyman D W, Orr-Weaver T L

Abstract excerpt

The ord gene is required for proper segregation of all chromosomes in both male and female Drosophila meiosis. Here we describe the isolation of a null ord allele and examine the consequences of ablating ord function. Cytologically, meiotic sister-chromatid cohesion is severely disrupted in flies lacking ORD protein. Moreover, the frequency of missegregation in genetic tests is consistent with random segregation...

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Identifiers

PMID: 9258677
DOI: 10.1093/genetics/146.4.1319
PMCID: PMC1208078

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