Linkage analysis of familial melanoma and chromosome 6 in 14 Australian kindreds.

doi:10.1002/(sici)1098-2264(199708)19:4<241::aid-gcc6>3.0.co;2-x

Back to search

Article

Linkage analysis of familial melanoma and chromosome 6 in 14 Australian kindreds.

Genes, chromosomes & cancer - 1 Aug 1997

Holland E A, Beaton S C, Kefford R F, Mann G J

Abstract excerpt

CDKN2A (9p21) and CDK4 (12q13) have been identified as melanoma susceptibility genes in certain familial melanoma (FM) kindreds. There remain other FM families, however, for which there is little or no evidence for linkage of melanoma to these loci. Other loci may be involved in susceptibility to...

Topics

Alleles
Australia
Chromosome Mapping
Chromosomes, Human, Pair 6
DNA
Genetic Heterogeneity
Genotype
Haplotypes
Humans
Likelihood Functions
Lod Score
Melanoma
Pedigree
Polymorphism, Genetic
Repetitive Sequences, Nucleic Acid

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.