Article
Confirmation of chromosome 9p linkage in familial melanoma.
American journal of human genetics - 1 Oct 1993
Nancarrow D J, Mann G J, Holland E A, Walker G J, Beaton S C, Walters M K, Luxford C, Palmer J M, Donald J A, Weber J L
Abstract excerpt
Malignant melanoma occurs as a familial cancer in 5%-10% of cases where it segregates in a manner consistent with autosomal dominant inheritance. Evidence from cytogenetics, fine-mapping studies of deletions in melanomas, and recent linkage studies supports the location of a human melanoma predisposition gene on the short arm of chromosome 9. We have carried out linkage analysis using the 9p markers IFNA and...
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