Article
Linkage analysis of extended high-risk pedigrees replicates a cutaneous malignant melanoma predisposition locus on chromosome 9q21.
The Journal of investigative dermatology - 1 Jan 2013
Cannon-Albright Lisa A, Teerlink Craig C, Farnham James M, Thomas Alun W, Zone John J, Leachman Sancy A
Abstract excerpt
Three predisposition genes have been identified for cutaneous malignant melanoma (CMM), but they account for only ∼25% of melanoma clusters/pedigrees. Linkage analyses of melanoma pedigrees from many countries have failed to identify significant linkage evidence for the remaining predisposition genes that must exist. The Utah linkage analysis approach of using singly informative extended high-risk pedigrees...
Topics
- Chromosomes, Human, Pair 9
- Denmark
- Female
- Genetic Linkage
- Genetic Loci
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Male
- Melanoma
- Pedigree
- Polymorphism, Single Nucleotide
- Skin Neoplasms