Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein

doi:10.1073/pnas.94.17.9273

Article

Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor protein

19 Aug 1997

Abstract excerpt

CTLA-4 plays a critical role in regulating the immune response. It is mainly located in cytoplasmic vesicles and is expressed only transiently on the surface after T cell activation. In this study, we demonstrate that CTLA-4 is associated with AP50, the medium chain of the clathrin-associated coated pit adaptor protein complex AP2. In a yeast two-hybrid screen, three individual cDNA clones that encode mouse AP50...

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