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Slp1 and Slp2‐a Localize to the Plasma Membrane of CTL and Contribute to Secretion from the Immunological Synapse

11 Feb 2008

Abstract excerpt

Rab27a is required for polarized secretion of lysosomes from cytotoxic T lymphocytes (CTLs) at the immunological synapse. A series of Rab27a-interacting proteins have been identified; however, only Munc13-4 has been found to be expressed in CTL. In this study, we screened for expression of the synaptotagmin-like proteins (Slps): Slp1/JFC1, Slp2-a/exophilin4, Slp3-a, Slp4/granuphilin, Slp5 and rabphilin in CTL. We...

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Identifiers

PMID: 18266782
DOI: 10.1111/j.1600-0854.2008.00714.x

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