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Article

CTLA-4 interacts with STAT5 and inhibits STAT5-mediated transcription.

Immunology - 1 Mar 2006

Srahna M, Van Grunsven L A, Remacle J E, Vandenberghe P

Abstract excerpt

Cytotoxic T-lymphocyte antigen-4 (CTLA-4; CD152) is a member of the immunoglobulin gene superfamily with strong homology to the receptor CD28 with which it shares the ligands CD80 and CD86. Unlike CD28, a potent costimulator of T-cell responses, CTLA-4 is transiently expressed on the cell surface of activated T cells and appears to operate predominantly as a negative regulator of T-cell proliferation. Signal...

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Share to Antigens, Differentiation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16476059
DOI: 10.1111/j.1365-2567.2005.02313.x
PMCID: PMC1782240

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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CTLA-4 interacts with STAT5 and inhibits STAT5-mediated transcription.PMID 16476059Read ↗

Interaction of the cytoplasmic tail of CTLA-4 (CD152) with a clathrin-associated protein is negatively regulated by tyrosine phosphorylation.Semantic proximity Read ↗

Cytotoxic T lymphocyte antigen 4 (CTLA-4) engagement delivers an inhibitory signal through the membrane-proximal region in the absence of the tyrosine motif in the cytoplasmic tail.Semantic proximity Read ↗

Structure-Function analysis of the CTLA-4 interaction with PP2A.Semantic proximity Read ↗

Interaction of CTLA-4 with AP50, a clathrin-coated pit adaptor proteinSemantic proximity Read ↗

Differences in CD80 and CD86 transendocytosis reveal CD86 as a key target for CTLA-4 immune regulationSemantic proximity Read ↗

The soluble CTLA-4 receptor and its role in autoimmune diseases: an updateSemantic proximity Read ↗

B7-independent inhibition of T cells by CTLA-4.Semantic proximity Read ↗

Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression.Semantic proximity Read ↗

Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses.Semantic proximity Read ↗

Molecular interactions of the CTLA-4 cytoplasmic region with the phosphoinositide 3-kinase SH2 domains.Semantic proximity Read ↗

Physical and Functional Interactions between STAT5 and Runx Transcription FactorsSemantic proximity Read ↗

The coactivator of transcription CREB-binding protein interacts preferentially with the glycosylated form of Stat5.Semantic proximity Read ↗

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