Article
Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jul 1997
Chuang E, Alegre M L, Duckett C S, Noel P J, Vander Heiden M G, Thompson C B
Abstract excerpt
CTLA-4 is a lymphocyte cell surface receptor expressed by activated T cells that functions to down-regulate T cell responses induced by TCR and CD28 stimulation. Since CTLA-4 competes with CD28 for binding to the common ligands B7-1 and B7-2, the level of CTLA-4 surface expression is likely to pl...
Topics
- Abatacept
- Adaptor Protein Complex 2
- Adaptor Protein Complex mu Subunits
- Adaptor Proteins, Vesicular Transport
- Amino Acid Sequence
- Antigens, CD
- Antigens, Differentiation
- CTLA-4 Antigen
- Endocytosis
- Humans
- Immunoconjugates
- Jurkat Cells
- Lymphocyte Activation
- Molecular Sequence Data
- Mutation
- Nerve Tissue Proteins
- Phosphoproteins
- Receptor Aggregation