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Article

Structural analysis of CTLA-4 function in vivo.

Journal of immunology (Baltimore, Md. : 1950) - 15 May 2000

Masteller E L, Chuang E, Mullen A C, Reiner S L, Thompson C B

Abstract excerpt

CTLA-4-mediated inhibition of T cell activation may be accomplished by competition for ligands and/or by signals mediated through the intracellular domain. Studies have implicated Tyr201 in the cytoplasmic domain of CTLA-4 in regulating CTLA-4 signal transduction and intracellular trafficking. To investigate the mechanism of CTLA-4 function in vivo, transgenes encoding wild-type CTLA-4 (FL), a mutant lacking the...

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Identifiers

PMID: 10799894
DOI: 10.4049/jimmunol.164.10.5319

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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