Article
Insertional mutation of the mouse Msx1 homeobox gene by an nlacZ reporter gene.
Mechanisms of development - 1 Jul 1997
Houzelstein D, Cohen A, Buckingham M E, Robert B
Abstract excerpt
We have generated a null allele of the mouse Msx1 homeobox gene by insertion of an nlacZ reporter gene into its homeobox. The sensitivity of beta-galactosidase detection permitted us to reveal novel aspects of Msx1 gene expression in heterozygous embryos, in particular in ectoderm and mesoderm during gastrulation, and in migrating neural crest cells. Homozygous mutant mice die at birth with facial defects (see...
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