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Article

Perinatal lethality and multiple craniofacial malformations in MSX2 transgenic mice.

Human molecular genetics - 1 Mar 1997

Winograd J, Reilly M P, Roe R, Lutz J, Laughner E, Xu X, Hu L, Asakura T, vander Kolk C, Strandberg J D, Semenza G L

Abstract excerpt

MSX2 is a homeodomain transcription factor that has been implicated in craniofacial morphogenesis on the basis of its expression pattern during mouse development and the finding of a missense mutation (P148H) in humans affected with Boston-type craniosynostosis. We have generated transgenic mice carrying a 34 kb DNA fragment encompassing a human MSX2 gene encoding either wild-type or mutant (P148H) MSX2....

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Source

Identifiers

PMID: 9147639
DOI: 10.1093/hmg/6.3.369

Genes

MSX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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