Article
Perinatal lethality and multiple craniofacial malformations in MSX2 transgenic mice.
Human molecular genetics - 1 Mar 1997
Winograd J, Reilly M P, Roe R, Lutz J, Laughner E, Xu X, Hu L, Asakura T, vander Kolk C, Strandberg J D, Semenza G L
Abstract excerpt
MSX2 is a homeodomain transcription factor that has been implicated in craniofacial morphogenesis on the basis of its expression pattern during mouse development and the finding of a missense mutation (P148H) in humans affected with Boston-type craniosynostosis. We have generated transgenic mice...
Topics
- Animals
- Apoptosis
- Craniofacial Abnormalities
- DNA-Binding Proteins
- Gene Expression Regulation, Developmental
- Genes, Homeobox
- Genotype
- Homeodomain Proteins
- Humans
- MSX1 Transcription Factor
- Mice
- Mice, Transgenic
- Morphogenesis
- Phenotype
- Skull
- Teratogens
- Transcription Factors