Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Estimation of the mtDNA mutation rate in aging mice by proteome analysis and mathematical modeling.

Experimental gerontology - 1 Jan 2006

Mao Lei, Zabel Claus, Wacker Maik A, Nebrich Grit, Sagi Dijana, Schrade Petra, Bachmann Sebastian, Kowald Axel, Klose Joachim

Abstract excerpt

The accumulation of mitochondria containing mutated genomes was proposed to be an important factor involved in aging. Although the level of mutated mtDNA has shown to increase over time, it is currently not possible to directly measure the mtDNA mutation rate within living cells. The combination of mathematical modeling and controlled experiments is an alternative approach to obtain an estimate for the mutation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to Electron Transport

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Electrophoresis, Gel, Two-Dimensional

Share to Mitochondria

Share to Mitochondria, Liver

Share to Mitochondrial Proteins

Share to Proteome

Share to Up-Regulation

Source

Identifiers

PMID: 16307857
DOI: 10.1016/j.exger.2005.09.012

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Estimation of the mtDNA mutation rate in aging mice by proteome analysis and mathematical modeling.PMID 16307857Read ↗

Mitochondrial DNA mutations and aging: devils in the details?Semantic proximity Read ↗

Germline and somatic mtDNA mutations in mouse aging.Semantic proximity Read ↗

The rate of mitochondrial mutagenesis is faster in mice than humans.Semantic proximity Read ↗

Ultra-deep sequencing of mouse mitochondrial DNA: mutational patterns and their origins.Semantic proximity Read ↗

Generation and Identification of Mutations Resulting in Chronic and Age-Related Phenotypes in Mice.Semantic proximity Read ↗

Mitochondrial mutations in mammalian aging: an over-hasty about-turn?Semantic proximity Read ↗

Mouse models of mitochondrial DNA defects and their relevance for human disease.Semantic proximity Read ↗

Accumulation of point mutations in mitochondrial DNA of aging mice.Semantic proximity Read ↗

Mutation theory of aging, assessed in transgenic mice and knockout mice.Semantic proximity Read ↗

Unbiased PCR-free spatio-temporal mapping of the mtDNA mutation spectrum reveals brain region-specific responses to replication instability.Semantic proximity Read ↗

Rethinking the Mitochondrial Theory of Aging: The Role of Mitochondrial Gene Expression in Lifespan DeterminationSemantic proximity Read ↗

Mouse models of mtDNA replication diseases.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.